Siraj Ahmad
, Zia Ullah Afridi, Bibi Shabana
This study presents a nonlinear mathematical model describing the interaction of uninfected cells, infected cells, viral particles, immune cells (T-cells), and chemotherapy. The analytical results establish that the system preserves biological feasibility, with all state variables remaining positive and bounded over time. Numerical simulations are carried out using biologically motivated parameters, and the results provide insights into the balance between viral replication, immune clearance, and chemotherapy dynamics. The findings highlight the critical role of immune T-cells and chemotherapy factors in shaping the infection outcome and suggest possible directions for improving therapeutic strategies through mathematical analysis.
Siraj Ahmad Zia Ullah Afridi Bibi Shabana “Modeling and Analysis of Tumor Growth under Virotherapy Chemotherapy and Immune System Dynamics” International Journal of Engineering Works Vol. 12 Issue 10 PP. 191-196 October 2025. https:// doi.org/10.5281/zenodo.17360342.
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